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Home / Drugs / Starting with A / Antipyrine
 
Antipyrine
 

An analgesic and antipyretic that has been given by mouth and as ear drops. Antipyrine is often used in testing the effects of other drugs or diseases on drug-metabolizing enzymes in the liver. (From Martindale, The Extra Pharmacopoeia, 30th ed, p29)
BrandsApirelina
Sedatin
Sedatine
PackagersD
h
SynonymsAcetasol
Analgesine
Anodynin
Anodynine
Antipirin
Antipyrin
Antipyrinum
Azophen
Azophenum
Fenazon [czech]
Fenazona [inn-spanish]
Fenazone
Phenazone
Phenozone

indication

Antipyrine is an analgesic often used to test effects of other drugs on liver enzymes..

pharmacology

Antipyrine is an analgesic and antipyretic that has been given by mouth and as ear drops. Antipyrine is often used in testing the effects of other drugs or diseases on drug-metabolizing enzymes in the liver. (From Martindale, The Extra Pharmacopoeia, 30th ed, p29)

mechanism of action

Antipyrine is thought to act primarily in the CNS, increasing the pain threshold by inhibiting both isoforms of cyclooxygenase, COX-1, COX-2, and COX-3 enzymes involved in prostaglandin (PG) synthesis.