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Home / Drugs / Starting with A / Antithymocyte globulin
 
Antithymocyte globulin
 

Rabbit anti-thymocyte globulin. Thymoglobulin is a polyclonal antibody that suppresses certain types of immune cells responsible for acute organ rejection in transplant patients. Thymoglobulin is a mixture of antibodies intended to bind to various cell surface antigens. The most common mode of action of Thymoglobulin is via selective depletion of T-cells.
BrandsATG-Fresenius
ATG-Fresenius S
Genzyme
Thymoglobulin SangStat Medical
CategoriesImmunomodulatory Agents
PackagersG
h
Synonymsrabbit ATG
rATG
Thymoglobulin

indication

For prevention of renal transplant rejection

pharmacology

Antithymocyte Globulin (ATG)is a concentrated anti-human T-lymphocyte immunoglobulin preparation derived from rabbits after immunization with a T-lympoblast cell line. ATG is an immunosuppressive product for the prevention and treatment of acute rejection following organ transplantation. ATG reduces the host immune response against tissue transplants or organ allografts.

mechanism of action

Binds to multiple, T-cell specific antigens leading to T-lymphocyte cell death via complement mediated cytotoxicity or apoptosis.

biotransformation

Most likely removed by opsonization via the reticuloendothelial system when bound to T lymphocytes, or by human antimurine antibody production.

half life

2-3 days