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Home / Drugs / Starting with B / Bethanidine
 
Bethanidine
 

A guanidinium antihypertensive agent that acts by blocking adrenergic transmission.
BrandsEsbatal
Tenathan
CategoriesAntihypertensive Agents
Adrenergic Agents
Sympatholytics
ManufacturersAh robins co
SynonymsBetanidine
Bethanidine sulfate

indication

For the treatment of hypertension.

pharmacology

Bethanidine is a guanidinium antihypertensive agent that acts by blocking adrenergic transmission. The precise mode of action is not clear. Although bethanidine may produce adverse effects, they are beneficial in severe hypertension and produce fewer side effects than guanethidine.

mechanism of action

Bethanidine, a guanidine derivative, is a peripherally acting antiadrenergic agent which primarily acts as an alpha2a adrenergic agonist. Bethanidine effectively decreases blood pressure by suppressing renin secretion or interfering with function of the sympathetic nervous system.

absorption

Absorbed rapidly in the gastrointestinal tract following oral administration.

half life

9 hours (range 7 to 11 hours)