indication

For the treatment of bacterial infections caused by susceptible microorganisms.

pharmacology

Cefoperazone is a third generation cephalosporin antibiotic. Cefoperazone exerts its bactericidal effect by inhibiting the bacterial cell wall synthesis

mechanism of action

Like all beta-lactam antibiotics, cefoperazone binds to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, causing the inhibition of the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins.

toxicity

Symptoms of overdose include blood in the urine, diarrhea, nausea, upper abdominal pain, and vomiting.

biotransformation

No significant quanitity of metabolites have been identified in urine.

half life

The mean serum half-life is approximately 2.0 hours, independent of the route of administration.

route of elimination

Cefoperazone is excreted mainly in the bile.

drug interactions

Amikacin: Increased risk of nephrotoxicity

Gentamicin: Increased risk of nephrotoxicity

Netilmicin: Increased risk of nephrotoxicity

Tobramycin: Increased risk of nephrotoxicity