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Home / Drugs / Starting with C / Ceforanide 		 
Ceforanide
  

Ceforanide is a second-generation parenteral cephalosporin antibiotic. It has a longer elimination half-life than any currently available cephalosporin. Its activity is very similar to that of cefamandole, a second-generation cephalosporin, except that ceforanide is less active against most gram-positive organisms. Many coliforms, including Escherichia coli, Klebsiella, Enterobacter, and Proteus, are susceptible to ceforanide, as are most strains of Salmonella, Shigella, Hemophilus, Citrobacter and Arizona species.
BrandsPrecef
CategoriesAnti-Bacterial Agents
Cephalosporins
ManufacturersApothecon inc div bristol myers squibb
Bristol laboratories inc div bristol myers co
SynonymsCeforanido [INN-Spanish]
Ceforanidum [INN-Latin]

indication

For the treatment of infections caused by susceptible organisms.

pharmacology

Ceforanide is a semisynthetic second-generation cephalosporin. The cephalosporins are bactericidal drugs with both gram-positive and gram-negative activity. They inhibit bacterial cell wall synthesis in a way similar to the penicillins.

mechanism of action

The bactericidal activity of ceforanide results from the inhibition of cell wall synthesis via affinity for penicillin-binding proteins (PBPs).

toxicity

Adverse effects following overdosage include nausea, vomiting, epigastric distress, diarrhea, and convulsions.

biotransformation

The major drug elimination route was urinary excretion with 85% of the dose being excreted unchanged in the urine within 12 hr, and no metabolites with antibiotic activity were observed in urine.

absorption

Rapidly absorbed following intramuscular injection.

half life

2.6 to 2.98 hours

drug interactions

Amikacin: Increased risk of nephrotoxicity

Gentamicin: Increased risk of nephrotoxicity

Netilmicin: Increased risk of nephrotoxicity

Tobramycin: Increased risk of nephrotoxicity

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