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Home / Drugs / Starting with C / Chlorphenesin
 
Chlorphenesin
 

A centrally acting muscle relaxant. Its mode of action is unknown. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1203)
BrandsAdermykon
Demykon
Gechophen
Gecophen
Maolate
Mycil
CategoriesMuscle Relaxants, Central
ManufacturersPharmacia and upjohn co
Synonymsalpha-Glyceryl ether
Chlorophenesin
Chlorphenesine [INN-French]
Chlorphenesinum [INN-Latin]
Clorfenesina [INN-Spanish]
p-Chlorophenyl
p-Chlorophenyl glyceryl ether

indication

Used, along with rest and physical therapy, to treat injuries and other painful muscular conditions. Investigated for use in trigeminal neuralgia (tic douloureux), a neuropathic disorder characterized by severe facial pain. Was investigated as a modulator of histamine release.

pharmacology

Chlorphenesin is a muscle relaxant. It blocks nerve impulses (or pain sensations) that are sent to the brain.

mechanism of action

The mechanism of action of chlorphenesin is not well defined, and its effects are measured mainly by subjective responses. It is known that chlorphenesin acts in the central nervous system (CNS) rather than directly on skeletal muscle.

toxicity

Symptoms of a chlorphenesin overdose include drowsiness and nausea.

biotransformation

Hepatic. 85% of a dose excreted within 24 hours as the glucuronide metabolite.

absorption

Rapid and complete.

half life

2.3-5 hours