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Home / Drugs / Starting with C / Clotiazepam
 
Clotiazepam
 

Clotiazepam is a benzodiazepine derivative, not approved for sale in the U.S. or Canada, but has been approved in the U.K. It is a schedule IV drug in Canada.
BrandsClozan
Distensan
Rize
Rizen
Tienor
Trecalmo
Veratran
CategoriesAnti-anxiety Agents
Hypnotics and Sedatives
Anticonvulsants
Benzodiazepines
SynonymsClotiazepamum [inn-latin]

indication

For the treatment of anxiety disorders.

pharmacology

Clotiazepam is a benzodiazepine derivative possessing anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant properties. Stage 2 NREM sleep is significantly increased by clotiazepam.

mechanism of action

Clotiazepam acts at the benzodiazepine receptors (BZD). This agonizes the action of GABA, increasing the frequency of opening of the channel chlorinates and penetration of the ions chlorinates through the ionophore. Increase in membrane polarization decreases the probability of discharge of neurons.

biotransformation

Hepatic.

half life

4 hours