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Home / Drugs / Starting with D / Daclizumab 		 
Daclizumab
  

Humanized IgG1 Mab that binds to the human interleukin-2 receptor (anti-Tac or anti-CD25). Daclizumab is a composite of human (90%) and murine (10%) antibody sequences. The human sequences were derived from the constant domains of human IgG1 and the variable framework regions of the Eu myeloma antibody. The murine sequences were derived from the complementarity-determining regions of a murine anti-Tac antibody.
BrandsZenapax (Hoffmann-La Roche Inc)
CategoriesImmunomodulatory Agents
Immunosuppressive Agents
PackagersF Hoffmann La Roche Ltd.
F Hoffmann-La Roche Ltd.
SynonymsAnti-IL-2
Humanized antiCD25
Ig gamma-1 chain C region

indication

Zenapax is a humanized monoclonal antibody used for prevention of renal transplant rejection

pharmacology

Zenapax functions as an IL-2 receptor antagonist. Specifically it inhibits IL-2-mediated activation of lymphocytes, a critical pathway in the cellular immune response involved in allograft rejection.

mechanism of action

Zenepax binds with high-affinity to the Tac subunit of the high-affinity IL-2 receptor complex and inhibits IL-2 binding. The IL-2 receptor (Tac) subunit is expressed on activated but not resting lymphocytes.

biotransformation

Most likely removed by opsonization via the reticuloendothelial system when bound to lymphocytes.

half life

11-38 days

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