Dalfopristin | Genelabs.com

Dalfopristin is a combination of two antibiotics (Dalfopristin and quinupristin) used to treat infections by staphylococci and by vancomycin-resistant Enterococcus faecium. It is not effective against Enterococcus faecalis infections. Dalfopristin inhibits the early phase of protein synthesis in the bacterial ribosome and quinupristin inhibits the late phase of protein synthesis.
Categories	Anti-Bacterial Agents Antibacterial Agents
Synonyms	Dalfopristina [inn-spanish] Dalfopristine [inn-french] Dalfopristinum [inn-latin]

For the treatment of bacterial infections (usually in combination with quinupristin).

Dalfopristin is a streptogramin antibiotic, derived from pristinamycin IIA.

The site of action of dalfopristin is the bacterial ribosome. Dalfopristin has been shown to inhibit the early phase of protein synthesis.

Converted to an active non-conjugated metabolite by hydrolysis.

The elimination half-life is approximately 0.70 hours.

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