Dienestrol | Genelabs.com

Dienestrol is a synthetic, non-steroidal estrogen. It is an estrogen receptor agonist. Estrogens work partly by increasing a normal clear discharge from the vagina and making the vulva and urethra healthy. Using or applying an estrogen relieves or lessens: dryness and soreness in the vagina, itching, redness, or soreness of the vulva. Conditions that are treated with vaginal estrogens include a genital skin condition (vulvar atrophy), inflammation of the vagina (atrophic vaginitis), and inflammation of the urethra (atrophic urethritis).
Brands	Agaldog Cycladiene Dienoestrol BP Dienol Dinestrol Dinovex DV Estragard Estraguard Estrodienol Estroral Follormon Gynefollin Hormofemin Isodienestrol Oestrasid Oestrodiene Oestrodienol Oestroral Oestrovis para-Dien Restrol Retalon Sexadien Synestrol Teserene Willnestrol
Categories	Estrogens, Non-Steroidal
Manufacturers	Ortho mcneil pharmaceutical inc Sanofi aventis us llc Solvay pharmaceuticals
Packagers	S h
Synonyms	Dehydrostilbestrol Dehydrostilboestrol Dienesterol Dienoestrol

indication

For use in the treatment of atrophic vaginitis and kraurosis vulvae.

pharmacology

Estrogens diffuse into their target cells and interact with a protein receptor. Target cells include the female reproductive tract, the mammary gland, the hypothalamus, and the pituitary. Estrogens increase the hepatic synthesis of sex hormone binding globulin (SHBG), thyroid-binding globulin (TBG), and other serum proteins and suppress follicle-stimulating hormone (FSH) from the anterior pituitary. The combination of an estrogen with a progestin suppresses the hypothalamic-pituitary system, decreasing the secretion of gonadotropin-releasing hormone (GnRH).

mechanism of action

Dienestrol is a synthetic, non-steroidal estrogen. Estrogens passively diffuse into target cells of responsive tissues, complex with the estrogen receptors, and enter the cell's nucleus to initiate or enhance gene transcription of protein synthesis after binding to DNA.

toxicity

Symptoms of overdose include nausea and vomiting, and withdrawal bleeding may occur in females.

biotransformation

Hepatic.

absorption

Systemic absorption and mode of action of dienestrol are undetermined.Estrogens diffuse into their target cells and interact with a protein receptor. Target cells include the female reproductive tract, the mammary gland, the hypothalamus, and the pituitary. Estrogens increase the hepatic synthesis of sex hormone binding globulin (SHBG), thyroid-binding globulin (TBG), and other serum proteins and suppress follicle-stimulating hormone (FSH) from the anterior pituitary. The combination of an estrogen with a progestin suppresses the hypothalamic-pituitary system, decreasing the secretion of gonadotropin-releasing hormone (GnRH).

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