indication

For use in the treatment of allergic rhinitis, hay fever, and allergic skin disorders.

pharmacology

Diphenylpyraline is an antihistamine that prevents, but does not reverse, responses mediated by histamine alone. Diphenylpyraline antagonizes most of the pharmacological effects of histamine, including urticaria and pruritus. Also, diphenylpyraline may exhibit anticholinergic actions (as do most of the antihistamines) and may thus provide a drying effect on the nasal mucosa.

mechanism of action

Antihistamines such as diphenylpyraline used in the treatment of allergy act by competing with histamine for H1-receptor sites on effector cells. This reduces the effects of histamine, leading to a temporary reduction of allergy symptoms.

biotransformation

Hepatic

absorption

Well absorbed after oral administration.

drug interactions

Donepezil: Possible antagonism of action

Galantamine: Possible antagonism of action