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Home / Drugs / Starting with H / Halazepam 		 
Halazepam
  

Halazepam is a benzodiazepine derivative. It possesses anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant properties. It is a trifluoromethyl derivative of nordazepam. While its structure may be similar to chlordiazepoxide and diazepam, it has both less toxicity and less tendency to cause paradoxical hostility and aggression than either of them. [Wikipedia]
BrandsPacinone
Paxipam
CategoriesAnti-anxiety Agents
Muscle Relaxants
Benzodiazepines
Sedative
ManufacturersSchering corp sub schering plough corp
SynonymsHalazepamum [INN-Latin]

indication

Used to relieve anxiety, nervousness, and tension associated with anxiety disorders.

mechanism of action

Benzodiazepines bind nonspecifically to benzodiazepine receptors BNZ1, which mediates sleep, and BNZ2, which affects affects muscle relaxation, anticonvulsant activity, motor coordination, and memory. As benzodiazepine receptors are thought to be coupled to gamma-aminobutyric acid-A (GABAA) receptors, this enhances the effects of GABA by increasing GABA affinity for the GABA receptor. Binding of GABA to the site opens the chloride channel, resulting in a hyperpolarized cell membrane that prevents further excitation of the cell.

biotransformation

Hepatic.

drug interactions

Cimetidine: Cimetidine may increase the effect of the benzodiazepine, halazepam.

Clozapine: Increased risk of toxicity

Fluconazole: Fluconazole may increase the effect of the benzodiazepine, halazepam.

Indinavir: The protease inhibitor, indinavir, may increase the effect of the benzodiazepine, halazepam.

Itraconazole: Itraconazole may increase the effect of the benzodiazepine, halazepam.

Ketoconazole: Ketoconazole may increase the effect of the benzodiazepine, halazepam.

Nelfinavir: The protease inhibitor, nelfinavir, may increase the effect of the benzodiazepine, halazepam.

Omeprazole: Omeprazole may increase the effect of the benzodiazepine, halazepam.

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