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Home / Drugs / Starting with L / Laronidase 		 
Laronidase
  

Human recombinant alpha-L-iduronidase, 628 residues (mature form), produced by recombinant DNAtechnology in a Chinese hamster ovary cell line. Laronidase is a glycoprotein with a molecular weight of approximately 83 kD. The predicted amino acid sequence of the recombinant form, as well as the nucleotide sequence that encodes it, are identical to a polymorphic form of human a-L-iduronidase. It contains 6 N-linked oligosaccharide modification sites.
BrandsAldurazyme
CategoriesEnzyme Replacement Agents
PackagersBioMarin Pharmaceuticals Inc.
Genzyme Inc.
Hollister-Stier Laboratories LLC
SynonymsAlpha-L-iduronidase precursor

indication

For the treatment of mucopolysaccharidosis

pharmacology

Laronidase is used to treat mucopolysaccharide storage disorders (specifically mucopolysaccharidosis 1 or Hurlers syndrome) caused by deficiencies of alpha-L-iduronidase. Reduced or absent a-L-iduronidase activity results in the accumulation of the GAG substrates, dermatan sulfate and heparan sulfate, throughout the body and leads to widespread cellular, tissue, and organ dysfunction.

mechanism of action

Laronidase catalyses the hydrolysis of terminal alpha-L-iduronic acid residues of dermatan sulfate and heparin sulfate.

half life

1.5-3.6 hrs

Terms of Use