Magnesium salicylate | Genelabs.com

Magnesium salicylate is a common analgesic and non-steroidal anti-inflammatory drug (NSAID) used to treat mild to moderate muscular pain. It is also used to treat headaches, general back pain, and certain joint pains like arthritis. It is found in a variety of over-the-counter (OTC) medications as an anti-inflammatory, primarily for back-pain relief. Magnesium Salicylate can be an effective OTC alternative to prescription NSAIDs, with both anti-inflamatory and pain-relieving effects. Though the recommended doseage is 1160 mg every six hours, per package directions of the Doan's OTC brand (580 mg magnesium salicylate tetrahydrate, equivalent to 934.4 mg anhydrous magnesium salicylate), effective pain relief is often found with a half dosage, with reduced anti-inflammatory results.

Packagers

Caraco Pharmaceutical Labs
CVS Pharmacy
Ivax Pharmaceuticals
Key Co.
Novartis AG
Palmetto Pharmaceuticals Inc.
Qualitest
US Pharmaceutical Corp.

indication

Magnesium salicylate is a common analgesic and non-steroidal anti-inflammatory drug (NSAID) used to treat mild to moderate muscular pain

mechanism of action

Most NSAIDs act as nonselective inhibitors of the enzyme cyclooxygenase (COX), inhibiting both the cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) isoenzymes. COX catalyzes the formation of prostaglandins and thromboxane from arachidonic acid (itself derived from the cellular phospholipid bilayer by phospholipase A2). Prostaglandins act (among other things) as messenger molecules in the process of inflammation.

drug interactions

Betamethasone: The corticosteroid, betamethasone, may decrease the effect of magnesium salicylate.

Dexamethasone: The corticosteroid, dexamethasone, may decrease the effect of magnesium salicylate.

Fludrocortisone: The corticosteroid, fludrocortisone, may decrease the effect of magnesium salicylate.

Gatifloxacin: Formation of non-absorbable complexes

Gemifloxacin: Formation of non-absorbable complexes

Gliclazide: The salicylate, magnesium salicylate, increases the effect of the sulfonylurea, gliclazide.

Glyburide: The salicylate, magnesium salicylate, increases the effect of the sulfonylurea, glibenclamide.

Hydrocortisone: The corticosteroid, hydrocortisone, may decrease the effect of magnesium salicylate.

Methazolamide: The salicylate, magnesium salicylate, at high dose increases the effect of the carbonic anhydrase inhibitor, methazolamide.

Methotrexate: The salicylate, magnesium salicylate, increases the effect and toxicity of methotrexate.

Minocycline: Formation of non-absorbable complexes

Prednisolone: The corticosteroid, prednisolone, may decrease the effect of magnesium salicylate.

Prednisone: The corticosteroid, prednisolone, may decrease the effect of magnesium salicylate.

Probenecid: The salicylate, magnesium salicylate, decreases the uricosuric effect of probenecid.

Quinidine: The antacid increases the effect of quinidine

Tetracycline: Formation of non-absorbable complexes

Triamcinolone: The corticosteroid, triamcinolone, may decrease the effect of magnesium salicylate.

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