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Home / Drugs / Starting with M / Meticillin
 
Meticillin
 

One of the penicillins which is resistant to penicillinase but susceptible to a penicillin-binding protein. It is inactivated by gastric acid so administered by injection. [PubChem]
BrandsDimocillin
Metacillin
CategoriesAnti-Bacterial Agents
Penicillins
ManufacturersApothecon inc div bristol myers squibb
Synonyms(2,6-Dimethoxyphenyl)penicillin
6-(2,6-Dimethoxybenzamido)penicillanic acid
Methicillinum
Methycillin
Meticilina [inn-spanish]
Meticilline [inn-french]
Meticillinum [inn-latin]

indication

Used to treat infections caused by susceptible Gram-positive bacteria, particularly beta-lactamase-producing organisms such as Staphylococcus aureus that would otherwise be resistant to most penicillins.

pharmacology

Meticillin (INN, BAN) or methicillin (USAN) is a narrow spectrum beta-lactam antibiotic of the penicillin class. It is no longer clinically used. Its role in therapy has been largely replaced by flucloxacillin and dicloxacillin, however the term methicillin-resistant Staphylococcus aureus (MRSA) continues to be used to describe Staphylococcus aureus strains resistant to all penicillins.

mechanism of action

Like other beta-lactam antibiotics, meticillin acts by inhibiting the synthesis of bacterial cell walls. It inhibits cross-linkage between the linear peptidoglycan polymer chains that make up a major component of the cell wall of Gram-positive bacteria. It does this by binding to and competitively inhibiting the transpeptidase enzyme used by bacteria to cross-link the peptide (D-alanyl-alanine) used in peptidogylcan synthesis.

biotransformation

Hepatic (20-40%).

absorption

Not absorbed following oral administration.

half life

25-60 minutes

drug interactions

Demeclocycline: Possible antagonism of action

Doxycycline: Possible antagonism of action

Ethinyl Estradiol: This anti-infectious agent could decrease the effect of the oral contraceptive