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Home / Drugs / Starting with N / Novobiocin
 
Novobiocin
 

An antibiotic compound derived from Streptomyces niveus. It has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, and blocks adenosine triphosphatase (ATPase) activity. (From Reynolds, Martindale The Extra Pharmacopoeia, 30th ed, p189) [PubChem]
BrandsAlbamix
Albamycin
Cardelmycin
Cathocin
Cathomycin
Inamycin
Novo-R
Robiocina
Sirbiocina
Spheromycin
Stilbiocina
Streptonivicin
CategoriesAnti-Bacterial Agents
Enzyme Inhibitors
Nucleic Acid Synthesis Inhibitors
ManufacturersPharmacia and upjohn co
SynonymsAntibiotic Pa-93
Crystallinic Acid
NOV
Novobiocina [INN-Spanish]
Novobiocine [INN-French]
Novobiocinum [INN-Latin]

indication

For the treatment of infections due to staphylococci and other susceptible organisms

pharmacology

Novobiocin is an aminocoumarin antibiotic that was produced by the actinomycete Streptomyces niveus. Novobiocin binds to DNA gyrase, and blocks adenosine triphosphatase (ATPase) activity. Other antibiotics in the aminocoumarin class include coumermycin A1 and clorobiocin.

mechanism of action

Novobiocin is an aminocoumarin. Aminocoumarins are very potent inhibitors of bacterial DNA gyrase and work by inhibiting the GyrB subunit of the enzyme involved in energy tranduction. Novobiocin as well as the other aminocoumarin antibiotics act as competitive inhibitors of the ATPase reaction catalysed by GyrB.

absorption

Oral bioavailability is negligible.

half life

6 hours