Ouabain | Genelabs.com

A cardioactive glycoside consisting of rhamnose and ouabagenin, obtained from the seeds of Strophanthus gratus and other plants of the Apocynaceae; used like digitalis. It is commonly used in cell biological studies as an inhibitor of the NA(+)-K(+)-exchanging ATPase. [PubChem]
Brands	Acocantherin Astrobain G-Strophicor Gratibain Gratus Strophanthin Kombetin Purostrophan Rectobaina Solufantina Strodival Strophalen Strophoperm Strophosan Uabaina Uabanin
Categories	Enzyme Inhibitors Cardiotonic Agents
Synonyms	G-Strophanthin Ouabagenin L-Rhamnoside Ouabain Octahydrate Ouabain, Octahydrate Ouabaine Strophanthin G Strophanthin-G

indication

For the treatment of atrial fibrillation and flutter and heart failure

pharmacology

Ouabain, a cardiac glycoside similar to digitoxin, is used to treat congestive heart failure and supraventricular arrhythmias due to reentry mechanisms, and to control ventricular rate in the treatment of chronic atrial fibrillation.

mechanism of action

Ouabain inhibits the Na-K-ATPase membrane pump, resulting in an increase in intracellular sodium and calcium concentrations. Increased intracellular concentrations of calcium may promote activation of contractile proteins (e.g., actin, myosin). Ouabain also acts on the electrical activity of the heart, increasing the slope of phase 4 depolarization, shortening the action potential duration, and decreasing the maximal diastolic potential.

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