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Home / Drugs / Starting with P / Pegvisomant 		 
Pegvisomant
  

Pegvisomant is a highly selective growth hormone (GH) receptor antagonist. It is used to treat acromegaly. Unlike dopamine or somatostatin analogs (which inhibit growth hormone secretion), this drug actually blocks the hepatic (GH-mediated) production of insulin like growth factor (IGF-1), which is the main mediator of growth hormone activity.
BrandsSomavert (Pfizer Inc)
CategoriesAnabolic Agents
Hormone Replacement Agents
ManufacturersPharmacia and upjohn co
PackagersHospira Inc.
Pfizer Inc.
Pharmacia Inc.
SynonymsGH
GH-N
Growth hormone
Growth hormone 1
Pituitary growth hormone
Somatotropin precursor

indication

Pegvisomant is a growth hormone receptor antagonist used for the treatment of acromegaly.

pharmacology

Somavert is used for the treatment of acromegaly, which arises from excessive IGF-1 levels. Somavert selectively binds to growth hormone (GH) receptors on cell surfaces, where it blocks the binding of endogenous GH, and thus interferes with GH signal transduction. Inhibition of GH action results in decreased serum concentrations of insulin-like growth factor-I (IGF-I), and IGF binding protein-3 (IGFBP-3). This reduces the symptoms of acromegaly.

mechanism of action

Somavert selectively binds to growth hormone (GH) receptors on cell surfaces, where it blocks the binding of endogenous GH. This leads to the normalization of serum IGF-1 levels.

half life

~6 days

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