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Home / Drugs / Starting with P / Phenylbutazone
 
Phenylbutazone
 

A drug that has anti-inflammatory, antipyretic, and analgesic activities. It is especially effective in the treatment of ankylosing spondylitis. It also is useful in rheumatoid arthritis and Reiter's syndrome (investigational indication). Although phenylbutazone is effective in gouty arthritis, risk/benefit considerations indicate that this drug should not be employed for this disease. (From AMA Drug Evaluations Annual, 1994, p1822)
Brands'Esteve'
Alindor
Alka Butazolidin
Alkabutazona
Alqoverin
Anerval
Anpuzone
Antadol
Anuspiramin
Apo-Phenylbutazone
Arthrizon
Artizin
Artrizin
Artrizone
Artropan
Azdid
Azobutyl
Azolid
B.T.Z.
Benzone
Betazed
Bizolin
Bizolin 200
Bunetzone
Busone
Buta Phen
Butacompren
Butacote
Butadion
Butadiona
Butadione
Butagesic
Butalgina
Butalidon
Butaluy
Butapirazol
Butapirazole
Butapyrazole
Butarecbon
Butartril
Butartrina
Butatron
Butazina
Butazolidin
Butazolidine
Butazona
Bute
Butidiona
Butiwas-Simple
Butone
Butoz
Butylpyrin
Buvetzone
Buzon
Chembutazone
Cotylbutazone
Digibutina
Diossidone
Diozol
Diphebuzol
Diphenylbutazone
Ecobutazone
Elmedal
Equi Bute
Equipalazone
Eributazone
Exrheudon N
Febuzina
Fenartil
Fenibutal
Fenibutasan
Fenibutazona
Fenibutol
Fenilbutazona
Fenilbutina
Fenilbutine
Fenilidina
Fenotone
Fenylbutazon
Ia-But
Intalbut
Intrabutazone
Intrazone
Ipsoflame
Kadol
Lingel
Malgesic
Mepha-Butazon
Mephabutazon
Mephabutazone
Merizone
Nadazone
Nadozone
Neo-Zoline
Novophenyl
Phebuzin
Phebuzine
Phenbutazol
Phenbutazone
Phenopyrine
Phenyl-Mobuzon
Phenylbutaz
Phenylbutazonum
Phenyzene
Phenyzone
Pirarreumol "B"
Pirarreumol B
Praecirheumin
Pyrabutol
Pyrazolidin
Rectofasa
Reudo
Reudox
Reumasyl
Reumazin
Reumazol
Reumune
Reumuzol
Reupolar
Robizon-V
Robizone
Robizone-V
Rubatone
Scanbutazone
Schemergin
Shigrodin
Tazone
Tencodyne
Tetnor
Tevcodyne
Therazone
Ticinil
Todalgil
Usaf Ge-15
Uzone
VAC-10
Wescozone
Zolaphen
Zolidinum
CategoriesAnti-inflammatory Agents
Nonsteroidal Anti-inflammatory Agents (NSAIAs)
ManufacturersSanofi aventis us llc
Novartis pharmaceuticals corp
Ivax pharmaceuticals inc
Mutual pharmaceutical co inc
Sandoz inc
Watson laboratories inc
PackagersC.O. Truxton Inc.
Jaapharm Canada Inc.
Medisca Inc.

indication

For the treatment of backache and ankylosing spondylitis

pharmacology

Phenylbutazone is a synthetic, pyrazolone derivative. It is a nonhormonal anti-inflammatory, antipyretic compound useful in the management of inflammatory conditions. The apparent analgesic effect is probably related mainly to the compound's anti-inflammatory properties and arise from its ability to reduce production of prostaglandin H and prostacyclin. Prostaglandins act on a variety of cells such as vascular smooth muscle cells causing constriction or dilation, on platelets causing aggregation or disaggregation and on spinal neurons causing pain. Prostacylcin causes vascular constriction platelet disaggregation

mechanism of action

Phenylbutazone binds to and inactivates prostaglandin H synthase and prostacyclin synthase through peroxide (H2O2) mediated deactivation. The reduced production of prostaglandin leads to reduced inflammation of the surrounding tissues.

toxicity

Oral, LD50 = 238 mg/kg (mouse); Oral, LD50 = 781 mg/kg (rabbit); Oral, LD50 = 245 mg/kg (rat); Oral, LD50 = 375 mg/kg (rat)

drug interactions

Acenocoumarol: The NSAID, phenylbutazone, may increase the anticoagulant effect of acenocoumarol.

Acetohexamide: Phenylbutazone may increase the effect of acetohexamide.

Anisindione: The NSAID, phenylbutazone, may increase the anticoagulant effect of anisindione.

Chlorpropamide: Phenylbutazone increases the effect of the hypoglycemic agent

Dicumarol: The NSAID, phenylbutazone, may increase the anticoagulant effect of dicumarol.

Ethotoin: The NSAID, phenylbutazone, may increase the hydantoin effect of ethotoin.

Fosphenytoin: The NSAID, phenylbutazone, may increase the hydantoin effect of fosphenytoin.

Gliclazide: Phenylbutazone increases the effect of the hypoglycemic agent

Glipizide: Phenylbutazone increases the effect of the hypoglycemic agent

Glisoxepide: Phenylbutazone increases the effect of the hypoglycemic agent

Glyburide: Phenylbutazone increases the effect of the hypoglycemic agent

Glycodiazine: Phenylbutazone increases the effect of the hypoglycemic agent

Lithium: The NSAID, phenylbutazone, may decrease the renal excretion of lithium. Increased risk of lithium toxicity.

Mephenytoin: The NSAID, phenylbutazone, may increase the hydantoin effect of mephenytoin.

Methotrexate: The NSAID, phenylbutazone, may decrease the renal excretion of methotrexate. Increased risk of methotrexate toxicity.

Phenytoin: The NSAID, phenylbutazone, may increase the therapeutic and adverse effects of phenytoin.

Tolazamide: Phenylbutazone increases the effect of the hypoglycemic agent

Tolbutamide: Phenylbutazone increases the effect of the hypoglycemic agent

Warfarin: The NSAID, phenylbutazone, may increase the anticoagulant effect of warfarin.