indication

For the treatment of asthma and chronic obstructive pulmonary disease (COPD).

pharmacology

Procaterol is a long-acting beta-2-adrenergic receptor agonist. It is a potent bronchodilator that may be administered orally or by aerosol inhalation.

mechanism of action

Beta(2)-receptor stimulation in the lung causes relaxation of bronchial smooth muscle, bronchodilation, and increased bronchial airflow.

toxicity

Symptoms of overdose include angina (chest pain), dizziness, dry mouth, fatigue, flu-like symptoms, headache, heart irregularities, high or low blood pressure, high blood sugar, insomnia, muscle cramps, nausea, nervousness, rapid heartbeat, seizures, and tremor.

absorption

Because of the small therapeutic dose, systemic levels of salmeterol are low or undetectable after inhalation of recommended doses.

drug interactions

Amitriptyline: The tricyclic antidepressant, amitriptyline, increases the sympathomimetic effect of procaterol.

Amoxapine: The tricyclic antidepressant, amoxapine, increases the sympathomimetic effect of procaterol.

Atenolol: Antagonism

Bisoprolol: Antagonism

Carvedilol: Antagonism

Clomipramine: The tricyclic antidepressant, clomipramine, increases the sympathomimetic effect of procaterol.

Desipramine: The tricyclic antidepressant, desipramine, increases the sympathomimetic effect of procaterol.

Doxepin: The tricyclic antidepressant, doxepin, increases the sympathomimetic effect of procaterol.

Esmolol: Antagonism

Imipramine: The tricyclic antidepressant, imipramine, increases the sympathomimetic effect of procaterol.

Isocarboxazid: Increased arterial pressure

Labetalol: Antagonism

Linezolid: Possible increase of arterial pressure

Methyldopa: Increased arterial pressure

Metoprolol: Antagonism

Midodrine: Increased arterial pressure

Moclobemide: Moclobemide increases the sympathomimetic effect of procaterol.

Nadolol: Antagonism

Nortriptyline: The tricyclic antidepressant, nortriptyline, increases the sympathomimetic effect of procaterol.

Phenelzine: Increased arterial pressure

Pindolol: Antagonism

Propranolol: Antagonism

Rasagiline: Increased arterial pressure

Reserpine: Increased arterial pressure

Timolol: Antagonism