indication

For the treatment of bacterial infections (usually in combination with dalfopristin).

pharmacology

Quinupristin is a streptogramin antibiotic, derived from pristinamycin I. By inhibiting the bacterial ribosomal subunits, protein synthesis is inhibited thus leading to eventual bacterial cell death or stasis.

mechanism of action

Quinupristin inhibits the late phase of protein synthesis in the bacterial ribosome. Dalfopristin binds to the 23S portion of the 50S ribosomal subunit, and changes the conformation it, enhancing the binding of quinupristin by a factor of about 100. In addition, it inhibits peptidyl transferase. Quinupristin binds to a nearby site on the 50S ribosomal subunit and prevents elongation of the polypeptide as well as causing incomplete chains to be released.

biotransformation

Quinupristin is converted to two conjugated active major metabolites, one with glutathione and one with cysteine.

half life

3.1 hours

drug interactions

Amlodipine: This combination presents an increased risk of toxicity

Arsenic trioxide: This combination presents an increased risk of toxicity

Astemizole: This combination presents an increased risk of toxicity

Atorvastatin: This combination presents an increased risk of toxicity

Carbamazepine: This combination presents an increased risk of toxicity

Cerivastatin: This combination presents an increased risk of toxicity

Cisapride: This combination presents an increased risk of toxicity

Clarithromycin: This combination presents an increased risk of toxicity

Cyclosporine: Synercid increases the effect of cyclosporine

Delavirdine: This combination presents an increased risk of toxicity

Diazepam: This combination presents an increased risk of toxicity

Dihydroquinidine barbiturate: This combination presents an increased risk of toxicity

Diltiazem: This combination presents an increased risk of toxicity

Disopyramide: This combination presents an increased risk of toxicity

Docetaxel: This combination presents an increased risk of toxicity.

Dofetilide: This combination presents an increased risk of toxicity

Droperidol: This combination presents an increased risk of toxicity

Erythromycin: This combination presents an increased risk of toxicity

Etoposide: This combination presents an increased risk of toxicity

Felbamate: This combination presents an increased risk of toxicity

Felodipine: This combination presents an increased risk of toxicity

Flecainide: This combination presents an increased risk of toxicity

Foscarnet: This combination presents an increased risk of toxicity

Fosphenytoin: This combination presents an increased risk of toxicity

Gatifloxacin: This combination presents an increased risk of toxicity

Grepafloxacin: This combination presents an increased risk of toxicity

Halofantrine: This combination presents an increased risk of toxicity

Indinavir: This combination presents an increased risk of toxicity

Isradipine: This combination presents an increased risk of toxicity

Lercanidipine: This combination presents an increased risk of toxicity

Levofloxacin: This combination presents an increased risk of toxicity

Levomethadyl Acetate: This combination presents an increased risk of toxicity

Lidocaine: This combination presents an increased risk of toxicity

Losartan: This combination presents an increased risk of toxicity

Lovastatin: This combination presents an increased risk of toxicity

Methylprednisolone: This combination presents an increased risk of toxicity

Midazolam: This combination presents an increased risk of toxicity

Moexipril: This combination presents an increased risk of toxicity

Moxifloxacin: This combination presents an increased risk of toxicity

Nevirapine: This combination presents an increased risk of toxicity

Nicardipine: This combination presents an increased risk of toxicity

Nifedipine: Synercid increases the effect of ziprasidone

Nimodipine: This combination presents an increased risk of toxicity

Nisoldipine: This combination presents an increased risk of toxicity

Octreotide: This combination presents an increased risk of toxicity

Paclitaxel: This combination presents an increased risk of toxicity

Pentamidine: This combination presents an increased risk of toxicity

Quetiapine: This combination presents an increased risk of toxicity

Quinidine: This combination presents an increased risk of toxicity

Quinidine barbiturate: This combination presents an increased risk of toxicity

Ritonavir: This combination presents an increased risk of toxicity

Salmeterol: This combination presents an increased risk of toxicity

Simvastatin: This combination presents an increased risk of toxicity

Tacrolimus: This combination presents an increased risk of toxicity

Tamoxifen: This combination presents an increased risk of toxicity

Teniposide: This combination presents an increased risk of toxicity

Terfenadine: This combination presents an increased risk of toxicity

Tizanidine: This combination presents an increased risk of toxicity

Venlafaxine: This combination presents an increased risk of toxicity

Verapamil: This combination presents an increased risk of toxicity

Vinblastine: This combination presents an increased risk of toxicity

Vincristine: This combination presents an increased risk of toxicity

Vindesine: This combination presents an increased risk of toxicity

Vinorelbine: This combination presents an increased risk of toxicity