Sodium lauryl sulfate | Genelabs.com

Sodium Lauryl Sulfate (SLS) is an anionic surfactant naturally derived from coconut and/or palm kernel oil. It usually consisting of a mixture of sodium alkyl sulfates, mainly the lauryl. SLS lowers surface tension of aqueous solutions and is used as fat emulsifier, wetting agent, and detergent in cosmetics, pharmaceuticals and toothpastes. It is also used in creams and pastes to properly disperse the ingredients and as research tool in protein biochemistry. SLS also has some microbicidal activity.
Brands	Adeka Hope LS 35 Adeka Hope LS 90 Akyposal NLS Akyposal SDS Alscoap LN 40A Alscoap LN 90 Alscoap MP 90N Alscoap SP 40 Alscoap-LN 90P Anticerumen Aquarex me Aquarex methyl Avirol 101 Avirol 118 conc Avirol SL 2010 Berol 452 Bio-Soft SDBS 60 Calfoam ES 303 Calfoam SLS 30 Carsonol SLS Carsonol SLS paste b Carsonol SLS special Carsonol SLS-s Caswell No. 779 Conco sulfate wa Conco sulfate WA-1200 Conco sulfate WA-1245 Conco sulfate WAG Conco sulfate WAN Conco sulfate WAS Conco sulfate WN Cycloryl 21 Cycloryl 21LS Cycloryl 31 Cycloryl 580 Cycloryl 585N Dehydag sulfate GL Dehydag sulfate GL emulsion Dehydag sulphate GL emulsion Dehydrag sulfate GL emulsion Dermacide Detergent 66 Dreft Dupanol waq Duponal Duponal waqe Duponol Duponol c Duponol ME Duponol methyl Duponol QC Duponol QX Duponol WA Duponol WA DRY Duponol WAQ Duponol waqa Duponol waqe Duponol waqm Emal 10 Emal 10 Needle Emal 10 Powder Emal 2F Emal 2F Needle Emal 2F30 Emal o Emal os Emersal 6400 Empicol 0303 Empicol 0303VA Empicol BSD 70 Empicol LPZ Empicol LS 30 Empicol LX 2 Empicol LX 28 Empicol LX 28R Empicol LX 42 Empicol LXSV 938U Empicol LXV Empicol LY 28S Empicol LZ/D Empimin SDS Emulsogen LS Equex S Equex SP Finasol OSR 2 Finasol osr(sub 2) Finasol OSR2 Fongrapol LSS Gardinol Gardinol type detergent Genapol LSS Hexamol SLS Incronol SLS Irium Jordanol SL-300 K 12 (surfactant) Lanette wax s Lanette wax-s Maprobix neu Maprofix 563 Maprofix LK Maprofix neu Maprofix wac Maprofix wac-la Melanol CL Melanol CL 30 Monagen Y 100 Monogen LH Monogen Y 100 Monogen Y 500 Montopol LA paste Needle 10 Neutrazyme Nikkol SLS Nissan persoft SP Nissan Sintrex L 100 Odoripon Al 95 Orvus WA Orvus WA paste Perklankrol ESD 60 Perlandrol L Perlankrol E.S.D. 60 Perlankrol L Pionin A 21 Polystep B 3 Polystep B 5 Quolac ex-ub Rewopol NLS 28 Rewopol NLS 30 Rhodapon LCP Rhodapon LSB Rhodapon SB Rhodapon SB 8208S Rhodapon SM Rhodapon UB Richonol A Richonol AF Richonol C Rolpon LS Rosulfan L 1 Sandet ona Silipon RN 6031 Sinnopon LS 100 Sinnopon LS 95 Sinolin 90TK-N Sintapon l Sintrex L 100 Sipex op Sipex SB Sipex SD Sipex SP Sipex ub Sipon LCS 98 Sipon LS Sipon LS 100 Sipon LSB Sipon PD Sipon ub Sipon WD Solsol needles Sorpol 5029O Sorpol 8070 Standapol 112 conc Standapol WA-AC Standapol WAQ Standapol WAQ special Standapol WAQ-LC Standapol WAS 100 Stanfax 234 Steinapol NLS Steinapol NLS 90 Stepanal WAC Stepanol ME Stepanol ME DRY Stepanol ME DRY AW Stepanol ME DRY SLS Stepanol methyl Stepanol methyl DRY AW Stepanol T 28 Stepanol WA Stepanol WA 100 Stepanol WA extra Stepanol WA paste Stepanol WA special Stepanol WA-100 Stepanol WAC Stepanol WAQ Sterling WA paste Sterling waq-CH Sterling waq-cosmetic Sulfetal L 95 Sulfochem SLS Sulfolyser Sulfopon T 30 Sulfopon WA 1 Sulfopon WA 1 Special Sulfopon WA 2 Sulfopon WA 3 Sulfopon WA1 Special Sulfopon WA2 Sulfopon WA3 Sulfotex WA Sulfotex wala Sunnol LM 1130 Supralate C Surfactant K12 Surfax 220 Swascol 1P Swascol 3L Swascol 4L Syntapon L Tarapon K 12 Texapon DL conc. Texapon K 12 Texapon K 1296 Texapon K 1298 Texapon K 12G Texapon K12 Texapon K1296 Texapon L 100 Texapon V HC Texapon V HC powder Texapon Z high conc. needles Texapon ZHC Trepenol WA Ufarol AM 30 Ufarol TCL 92 Ultra sulfate SL-1 WAQE Witcolate A
Categories	Surface-Active Agents
Packagers	Amend Carrington Coopersurgical Inc. Nutricia
Synonyms	Dodecyl alcohol, hydrogen sulfate, sodium salt Dodecyl sodium sulfate Dodecyl sulfate sodium Dodecyl sulfate sodium salt Dodecyl sulfate, sodium salt Lauryl sodium sulfate Lauryl sulfate sodium Lauryl sulfate sodium salt Lauryl sulfate, sodium salt Laurylsiran sodny [czech] Lauyl sodium sulfate Monododecyl sodium sulfate N-dodecyl sulfate sodium NADDS NALS Natrium laurylsulfuricum Natriumlaurylsulfat SDS Sodium dodecyl sulfate Sodium lauryl sulphate Sodium monododecyl sulfate Sodium monolauryl sulfate Sodium n-dodecyl sulfate Sodiumlauryl ether sulfate Sulfuric acid dodecyl ester sodium salt Sulfuric acid monododecyl ester sodium salt Sulfuric acid, monododecyl ester, sodium salt

indication

SLS is used as a surfactant in shampoos and toothpastes. SLS also has microbicidal activities against both enveloped (Herpes simplex viruses, HIV-1, Semliki Forest virus) and nonenveloped (papillomaviruses, reovirus, rotavirus and poliovirus) viruses, although it has not been approved for this use.

pharmacology

SLS is an anionic surfactant. Its amphiphilic properties make it an ideal detergent.

mechanism of action

Like other surfactants, SLS is amphiphilic. It thus migrates to the surface of liquids, where its alignment and aggregation with other SLS molecules lowers the surface tension. This allows for easier spreading and mixing of the liquid. SLS has potent protein denaturing activity and inhibits the infectivity of viruses by by solubilizing the viral envelope and/or by denaturing envelope and/or capsid proteins.

toxicity

Oral (LD50): Acute: 1288 mg/kg [Rat]

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