Tolazoline | Genelabs.com

A vasodilator that apparently has direct actions on blood vessels and also increases cardiac output. Tolazoline can interact to some degree with histamine, adrenergic, and cholinergic receptors, but the mechanisms of its therapeutic effects are not clear. It is used in treatment of persistent pulmonary hypertension of the newborn. [PubChem]
Brands	Artonil Benzazoline Benzidazol Benzolin Benzylimidazoline Dilatol Asi Divascol Imidalin Imidaline Kasimid Lambril Olitensol Peripherine Phenylmethylimidazoline Prefaxil Priscol Priscoline Tolazolin Vasimid Vasodil Vasodilatan
Categories	Antihypertensive Agents Vasodilator Agents Adrenergic alpha-Antagonists
Manufacturers	Novartis pharmaceuticals corp
Packagers	N h

indication

For the treatment of pulmonary artery anomalies

pharmacology

Tolazoline is a pulmonary vasodilator indicated used to decrease pulmonary vascular resistance (PVR) in persistent pulmonary hypertension of the newborn (PPHN).

mechanism of action

Vasodilation by means of a direct effect on peripheral vascular smooth muscle and indirect effects produced, in part, by release of endogenous histamine; tolazoline has moderate alpha-adrenergic blocking activity and has histamine agonist activity. Tolazoline usually reduces pulmonary arterial pressure and vascular resistance.

drug interactions

Cimetidine: Anticipated loss of efficacy of tolazoline

Ranitidine: Anticipated loss of efficacy of tolazoline

Treprostinil: Additive hypotensive effect. Monitor antihypertensive therapy during concomitant use.

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