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Home / Drugs / Starting with T / Tolnaftate
 
Tolnaftate
 

Tolnaftate is a synthetic over-the-counter anti-fungal agent. It may come as a cream, powder, spray, or liquid aerosol, and is used to treat jock itch, athlete's foot and ringworm. It is sold under several brand names, most notably Tinactin (Schering-Plough Corporation) and Odor Eaters (Combe Incorporated). Other brands are Absorbine, Aftate, Desenex, Genaspor, NP 27, and Ting.
Brands2-Naphthyl N-methyl-N-(3-tolyl)thionocarbamate
Aftate
Aftate for athlete's foot aerosol spray liquid
Aftate for athlete's foot aerosol spray powder
Aftate for athlete's foot gel
Aftate for athlete's foot sprinkle powder
Aftate for jock itch aerosol spray powder
Aftate for jock itch gel
Aftate for jock itch sprinkle powder
Carbanilic acid, M,N-dimethylthio-, O-2-naphthyl ester
Carbanilic acid, N,M-dimethylthio-, O-2-naphthyl ester
Chinofungin
Dermoxin
Dr. Scholl's athlete's foot spray
Dungistop
Focusan
Fungistop
Genaspore cream
Hi-alarzin
Hi-alazin
M,N-Dimethylthiocarbanilic acid O-2-naphthyl ester
Naphthiomate T
Naphthiomate-t
NP-27 Cream
NP-27 Powder
NP-27 Solution
NP-27 Spray Powder
o-(2-Naphthyl) methyl(3-methylphenyl)thiocarbamate
O-2-Naphthyl M,N-dimethylthiocarbanilate
O-2-Naphthyl N,N-dimethylthiocarbanilate
Phytoderm
Pitrex
Pitrex cream
Prestwick_472
Separin
Separin (TN)
Sorgoa
Sporiline
Timoped
Tinactin
Tinactin (TN)
Tinactin aerosol liquid
Tinactin aerosol powder
Tinactin antifungal deodorant powder aerosol
Tinactin cream
Tinactin jock itch aerosol powder
Tinactin jock itch cream
Tinactin jock itch spray powder
Tinactin plus aerosol powder
Tinactin plus powder
Tinactin powder
Tinactin solution
Tinaderm
Tinavet
Tinavet (veterinary)
Ting antifungal cream
Ting antifungal powder
Ting antifungal spray liquid
Ting antifungal spray powder
Ting products
Tniaderm
Tolnaftate (JP14/USP)
Tolnaftate (JP15/USP)
Tolnaftate [usan:ban:inn:jan]
Tolnaftate(USAN)
Tolnaftato [DCIT]
Tolnaftato [inn-spanish]
Tolnaftatum [inn-latin]
Tolnaphthate
Tolsanil
Tonoftal
Tritin
Zeasorb-AF powder
CategoriesAntifungal Agents
PackagersChain Drug
Medisca Inc.
Perrigo Co.
S&P Healthcare
Stiefel Labs

indication

Tolnaftate topical is used to treat skin infections such as athlete's foot, jock itch, and ringworm infections. Tolnaftate is also used, along with other antifungals, to treat infections of the nails, scalp, palms, and soles of the feet. The powder and powder aerosol may be used to prevent athlete's foot.

pharmacology

Tolnaftate is a synthetic over-the-counter anti-fungal agent.

mechanism of action

Tolnaftate is a topical fungicide. Though its exact mechanism unknown, it is believed to prevent ergosterol biosynthesis by inhibiting squalene epoxidase. It has also been reported to distort the hyphae and to stunt mycelial growth in susceptible organisms.

toxicity

Oral rat LD50: 891 mg/kg. Inhalation rat LC50: > 900 mg/m3/1hr. Irritation: skin rabbit: 500 mg/24H mild. Eye rabbit: 100 mg severe. Investigated a mutagen and reproductive effector.