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Home / Drugs / Starting with U / Uracil mustard
 
Uracil mustard
 

Nitrogen mustard derivative of uracil. It is a alkylating antineoplastic agent that is used in lymphatic malignancies, and causes mainly gastrointestinal and bone marrow damage. [PubChem]
BrandsAminouracil Mustard
Chlorethaminacil
Demethyldopan
Desmethyldopan
Haemanthamine
Nordopan
Uracil nitrogen mustard
Uracillost
Uracilmostaza
Uramustin
Uramustine
CategoriesAntineoplastic Agents
Antineoplastic Agents, Alkylating
ManufacturersShire development inc

indication

Used for its antineoplastic properties.

pharmacology

Uracil Mustard selectively inhibits the synthesis of deoxyribonucleic acid (DNA). The guanine and cytosine content correlates with the degree of Uracil Mustard-induced cross-linking. At high concentrations of the drug, cellular RNA and protein synthesis are also suppressed.

mechanism of action

After activation, it binds preferentially to the guanine and cytosine moieties of DNA, leading to cross-linking of DNA, thus inhibiting DNA synthesis and function.