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Research Publications
 
2004
Title: HCV Antiviral Agents
Authors: Ronald C. Griffith, Lillian Lou, Christopher D. Roberts and Uli Schmitz
Publication: Annual Reports in Medicinal Chemistry 2004, 39, 223
 
Title: A novel assay to determine the sequence preference and affinity of DNA minor
groove binding compounds.
Authors: Thomas R, Gonzalez C, Roberts C, Botyanszki J, Lou L, Michelotti EF.
Publication: Nucleic Acids Res. 2004 Jan 12;32(1):e8.
 
2002
Title: DNA binding compounds targeting fungal pathogens: an emerging concept in the
discovery of novel antifungal agents.
Authors: Lou L, Velligan M, Roberts C, Stevens DA, Clemons KV.
Publication: Curr Opin Investig Drugs.
2002 Oct;3(10):1437-45. Review.
 
Title: Minor-groove DNA Binders as Antimicrobial Agents.1. Pyrrole tetraamides are potent antibacterials against Vancomycin Resistant Enteroccoci and Methicillin Resistant Staphylococcus aureus.
Authors: Dyatkina NB, Roberts CD, Keicher JD, Dai Y, Nadherny JP, Zhang W, Schmitz U, Kongpachith A, Fung K, Novikov AA, Lou L, Velligan M, Khorlin AA, Chen MS
Publication: J. Med.Chem., 2002 45(4):805-17


2001
Title: A novel dicationic polyamide ligand binds in the DNA minor groove as a dimer.
Authors: Zhang W, Dai Y, Schmitz U, Bruice TW
Publication: FEBS Lett., 2001:509:85-89

Title: Allosteric interactions of minor groove binding ligands with UL9-DNA complexes.
Authors: Kwok Y, Zhang W, Schroth GP, Liang Ch, Alexi N, Bruice TW
Publication: Biochemistry, 2001:40:12628-12638

Title: The hybridization-stabilization assay: a solution-based isothermal method for rapid screening and determination of sequence preference of ligands that bind to duplexed nucleic acids.
Authors: Gonzalez C, Moore M, Ribeiro S, Schmitz U, Schroth GP, Turin L, Bruice TW
Publication: Nucleic Acids Res., 2001: 29(16):E85

Title: Specific down-regulation of an engineered human cyclin D1 promoter by a novel DNA-binding ligand in intact cells.
Authors: Laurance ME, Starr DB, Michelotti EF, Cheung E. Gonzalez C, Tam AW, Deikman J, Edwards CA, Bardwell AJ
Publication: Nucleic Acids Res., 2001: 29(3):652-618