indication

Used to treat the symptoms of asthma, bronchitis, and emphysema.

pharmacology

Oxtriphylline is a bronchodilator. Oxtriphylline works in several ways: it relaxes muscles in your lungs and chest to allow more air in, decreases the sensitivity of your lungs to allergens and other substances that cause inflammation, and increases the contractions of your diaphragm to draw more air into the lungs.

mechanism of action

Oxtriphylline is a choline salt of theophylline. Oxtriphylline relaxes the smooth muscle of the bronchial airways and pulmonary blood vessels and reduces airway responsiveness to histamine, methacholine, adenosine, and allergen. Oxtriphylline competitively inhibits type III and type IV phosphodiesterase (PDE), the enzyme responsible for breaking down cyclic AMP in smooth muscle cells, possibly resulting in bronchodilation. Oxtriphylline also binds to the adenosine A2B receptor and blocks adenosine mediated bronchoconstriction.

toxicity

Symptoms of toxicity include abdominal pain (continuing or severe), confusion or change in behavior, convulsions (seizures), dark or bloody vomit, diarrhea, dizziness or lightheadedness, fast and/or irregular heartbeat, nervousness or restlessness (continuing), and trembling (continuing).

drug interactions

Aciclovir: Aciclovir may increase the effect and toxicity of oxtriphylline.

Adenosine: This xanthine decreases the effect of adenosine

Amobarbital: The barbiturate, amobarbital, decreases the effect of oxtriphylline.

Aprobarbital: The barbiturate, aprobarbital, decreases the effect of oxtriphylline.

Atracurium: Theophylline decreases the effect of muscle relaxant

Butabarbital: The barbiturate, butabarbital, decreases the effect of oxtriphylline.

Butalbital: The barbiturate, butalbital, decreases the effect of oxtriphylline.

Butethal: The barbiturate, butethal, decreases the effect of oxtriphylline.

Carbamazepine: Carbamazepine may decrease the serum concentration of oxtriphylline. Oxtriphylline may decrease the serum concentration of carbamazepine. Monitor for changes in the therapeutic effect of both agents if concomitant therapy is initiated, discontinued or dose changed.

Carteolol: Antagonism of action and increased effect of theophylline

Cimetidine: Cimetidine may increase the serum concentration of oxtriphylline by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of oxtriphylline if cimetidine is initiated, discontinued or dose changed.

Ciprofloxacin: Ciprofloxacin may increase the effect of oxtriphylline.

Clarithromycin: Clarithromycin may increase the effect and toxicity of oxtriphylline.

Dihydroquinidine barbiturate: The barbiturate, dihydroquinidine barbiturate, decreases the effect of oxtriphylline.

Disulfiram: Disulfiram may increase the effect and toxicity of oxtriphylline.

Doxacurium chloride: Theophylline decreases the effect of muscle relaxant

Enoxacin: Enoxacin may increase the effect of oxtriphylline.

Erythromycin: The macrolide, erythromycin, may increase the effect and toxicity of the theophylline derivative, oxtriphylline.

Ethinyl Estradiol: The contraceptive increases the effect and toxicity of theophylline

Ethotoin: Decreased effect of both products

Fluvoxamine: Fluvoxamine may increase the therapeutic and adverse effects of oxtriphylline.

Fosphenytoin: Decreased effect of both products

Grepafloxacin: Grepafloxacin may increase the effect of oxtriphylline.

Halothane: Increased risk of cardiac arrhythmia

Heptabarbital: The barbiturate, heptabarbital, decreases the effect of oxtriphylline.

Hexobarbital: The barbiturate, hexobarbital, decreases the effect of oxtriphylline.

Interferon Alfa-2a, Recombinant: Interferon increases the effect and toxicity of theophylline

Interferon Alfa-2b, Recombinant: Interferon increases the effect and toxicity of theophylline

Interferon alfa-n1: Interferon increases the effect and toxicity of theophylline

Isoniazid: Isoniazid may increase the effect and toxicity of oxtriphylline.

Josamycin: The macrolide, josamycin, may increase the effect and toxicity of the theophylline derivative, oxtriphylline.

Lithium: Theophylline decreases serum levels of lithium

Mephenytoin: Decreased effect of both products

Mestranol: The contraceptive increases the effect and toxicity of theophylline

Methohexital: The barbiturate, methohexital, decreases the effect of oxtriphylline.

Methylphenobarbital: The barbiturate, methylphenobarbital, decreases the effect of oxtriphylline.

Metocurine: Theophylline decreases the effect of muscle relaxant

Mexiletine: Mexiletine increases the effect and toxicity of theophylline

Mivacurium: Theophylline decreases the effect of muscle relaxant

Nadolol: Antagonism of action and increased effect of theophylline

Norfloxacin: Norfloxacin may increase the effect of oxtriphylline.

Pancuronium: Theophylline decreases the effect of muscle relaxant

Pefloxacin: Pefloxacin may increase the effect of oxtriphylline.

Peginterferon alfa-2a: Interferon increases the effect and toxicity of theophylline

Peginterferon alfa-2b: Interferon increases the effect and toxicity of theophylline

Penbutolol: Antagonism of action and increased effect of theophylline

Pentobarbital: The barbiturate, pentobarbital, decreases the effect of oxtriphylline.

Pentoxifylline: Pentoxifylline increases the effect and toxicity of theophylline

Phenobarbital: The barbiturate, phenobarbital, decreases the effect of oxtriphylline.

Phenytoin: Decreased effect of both products

Pindolol: Antagonism of action and increased effect of theophylline

Primidone: The barbiturate, primidone, decreases the effect of oxtriphylline.

Propafenone: Propafenone increases the effect of theophylline

Propranolol: Antagonism of action and increased effect of theophylline

Quinidine barbiturate: The barbiturate, quinidine barbiturate, decreases the effect of oxtriphylline.

Rifampin: Rifampin may decrease the effect and toxicity of oxtriphylline.

Ritonavir: Ritonavir decreases the effect of theophylline

Rofecoxib: Rofecoxib increases the effect and toxicity of theophylline

Secobarbital: The barbiturate, secobarbital, decreases the effect of oxtriphylline.

Sotalol: Antagonism of action and increased effect of theophylline

St. John's Wort: St. John's Wort decreases the effect of theophylline

Tacrine: Tacrine increases the effect and toxicity of theophylline

Talbutal: The barbiturate, talbutal, decreases the effect of oxtriphylline.

Terbinafine: Terbinafine increases the effect and toxicity of theophylline

Thiabendazole: Thiabendazole increases the effect and toxicity of theophylline

Ticlopidine: Ticlopidine increases the effect and toxicity of theophylline

Timolol: Antagonism of action and increased effect of theophylline

Troleandomycin: The macrolide, troleandomycin, may increase the effect and toxicity of the theophylline derivative, oxtriphylline.

Tubocurarine: Theophylline decreases the effect of muscle relaxant

Vecuronium: Theophylline decreases the effect of muscle relaxant

Verapamil: Verapamil increases the effect of theophylline

Zileuton: Zileuton increases the effect and toxicity of theophylline