indication

For use as a sedative and hypnotic.

pharmacology

Talbutal is a short to intermediate-acting barbiturate. Barbiturates act as nonselective depressants of the central nervous system (CNS), capable of producing all levels of CNS mood alteration from excitation to mild sedation, hypnosis, and deep coma. In sufficiently high therapeutic doses, barbiturates induce anesthesia.

mechanism of action

Talbutal binds at a distinct binding site associated with a Cl^- ionopore at the GABA_A receptor, increasing the duration of time for which the Cl^- ionopore is open. The post-synaptic inhibitory effect of GABA in the thalamus is, therefore, prolonged.

toxicity

Symptoms of acute barbiturate poisoning include drowsiness, confusion, coma, respiratory depression, hypotension, and shock.

drug interactions

Aminophylline: The barbiturate, talbutal, decreases the effect of aminophylline.

Betamethasone: The barbiturate, talbutal, may decrease the effect of the corticosteroid, betamethasone.

Clomifene: The enzyme inducer, talbutal, decreases the effect of the hormone agent, clomifene.

Conjugated Estrogens: The enzyme inducer, talbutal, decreases the effect of the hormone agent, conjugated estrogens.

Cyclosporine: The sulfonamide decreases the effect of cyclosporine

Dexamethasone: The barbiturate, talbutal, may decrease the effect of the corticosteroid, dexamethasone.

Diethylstilbestrol: The enzyme inducer, talbutal, decreases the effect of the hormone agent, diethylstilbestrol.

Doxycycline: The anticonvulsant, talbutal, decreases the effect of doxycycline.

Estradiol: The enzyme inducer, talbutal, decreases the effect of the hormone agent, estradiol.

Ethinyl Estradiol: This product may cause a slight decrease of contraceptive effect

Felodipine: The barbiturate, talbutal, decreases the effect of felodipine.

Fludrocortisone: The barbiturate, talbutal, may decrease the effect of the corticosteroid, fludrocortisone.

Folic Acid: Folic acid decreases the effect of anticonvulsant, talbutal.

Gefitinib: The CYP3A4 inducer, talbutal, may decrease the serum concentration and therapeutic effects of gefitinib.

Griseofulvin: The barbiturate, talbutal, decreases the effect of griseofulvin.

Hydrocortisone: The barbiturate, talbutal, may decrease the effect of the corticosteroid, hydrocortisone.

Levonorgestrel: Phenobarbital decreases the effect of levonorgestrel

Medroxyprogesterone: The enzyme inducer, talbutal, decreases the effect of the hormone agent, medroxyprogesterone.

Megestrol: The enzyme inducer, talbutal, decreases the effect of the hormone agent, megestrol.

Methadone: The barbiturate, talbutal, decreases the effect of methadone.

Metronidazole: The barbiturate, talbutal, decreases the effect of metronidazole.

Nifedipine: The barbiturate, talbutal, decreases the effect of the calcium channel blocker, nifedipine.

Norethindrone: This product may cause a slight decrease of contraceptive effect

Oxtriphylline: The barbiturate, talbutal, decreases the effect of oxtriphylline.

Prednisolone: The barbiturate, talbutal, may decrease the effect of the corticosteroid, prednisolone.

Prednisone: The barbiturate, talbutal, may decrease the effect of the corticosteroid, prednisone.

Quinidine: The anticonvulsant, talbutal, decreases the effect of quinidine.

Theophylline: The barbiturate, talbutal, decreases the effect of theophylline.

Triamcinolone: The barbiturate, talbutal, may decrease the effect of the corticosteroid, triamcinolone.